Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

11p15.5

lncRNA

H19 ( ENSG00000130600)

miRNA

hsa-miR-125a-3p (MIMAT0004602)

mRNA

EZH2 (ENSG00000106462)

Disease

UVM

FDR

5.36E-4

Reported as biomarkers
15

Circulating
13

Drug resistent
52

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3                 U           A 5 hsa-miR-125a-3p
           CCGA     GGGUUC UGGAGUGG AC    
           GGCU     CCCGAG GCCUCACC UG    
target 5 C    GUGUG               C  C 3 H19
Start: 629  End: 649
Energy: -33.4 kcal/mol
Align Score: 0.004419
miRNA  3                 U           A 5 hsa-miR-125a-3p
           CCGA     GGGUUC UGGAGUGG AC    
           GGCU     CCCGAG GCCUCACC UG    
target 5 C    GUGUG               C  C 3 H19
Start: 1483  End: 1503
Energy: -33.4 kcal/mol
Align Score: 0.009996
miRNA  3                 U           A 5 hsa-miR-125a-3p
           CCGA     GGGUUC UGGAGUGG AC    
           GGCU     CCCGAG GCCUCACC UG    
target 5 C    GUGUG               C  C 3 H19
Start: 1333  End: 1353
Energy: -33.4 kcal/mol
Align Score: 0.008863
miRNA  3                 U           A 5 hsa-miR-125a-3p
           CCGA     GGGUUC UGGAGUGG AC    
           GGCU     CCCGAG GCCUCACC UG    
target 5 C    GUGUG               C  C 3 H19
Start: 1373  End: 1393
Energy: -33.4 kcal/mol
Align Score: 0.009113
miRNA  3         U      A   G     A 5 hsa-miR-125a-3p
           CCGAGGG UCUUGG GUG    AC    
           GGCUCCC AGAACC CAC    UG    
target 5 G                  AACA  A 3 H19
Start: 276  End: 296
Energy: -33.3 kcal/mol
Align Score: 0.005033

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for H19

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-125a-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for EZH2

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 11p15.5

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.