Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

17p11.2

lncRNA

LRRC75A-AS1 ( ENSG00000175061)

miRNA

hsa-miR-3127-5p (MIMAT0014990)

mRNA

PHLPP1 (ENSG00000081913)

Disease

SKCM

FDR

2.83E-7

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'   GAAGGGUAAGGUGUUCGGGACUA 5' hsa-miR-3127-5p
                           ||||||| 
target 5'   AACUGCCAGAGCCCUGCCCUGAA LRRC75A-AS1
Start: 190  End: 197
Site type: 8mer-1a
Context++ Score: -0.415
miRNA  3'  GAAGGGUAAGGUGUUCGGGACUA 5' hsa-miR-3127-5p
                          ||||||| 
target 5'  GACUCCCUCAGAAAGGCCCUGAA LRRC75A-AS1
Start: 644  End: 651
Site type: 8mer-1a
Context++ Score: -0.402
miRNA  3'   GAAGGGUAAGGUGUUCGGGACUA 5' hsa-miR-3127-5p
                           ||||||| 
target 5'   AACUGCCAGAGCCCUGCCCUGAA LRRC75A-AS1
Start: 158  End: 165
Site type: 8mer-1a
Context++ Score: -0.423
miRNA  3'   GAAGGGUAAGGUGUUCGGGACUA 5' hsa-miR-3127-5p
                           ||||||| 
target 5'   AACUGCCAGAGCCCUGCCCUGAA LRRC75A-AS1
Start: 194  End: 201
Site type: 8mer-1a
Context++ Score: -0.414
miRNA  3'   GAAGGGUAAGGUGUUCGGGACUA 5' hsa-miR-3127-5p
                           ||||||| 
target 5'   AACUGCCAGAGCCCUGCCCUGAA LRRC75A-AS1
Start: 135  End: 142
Site type: 8mer-1a
Context++ Score: -0.429
RNAbybrid target site prediction
miRNA  3' GA    UA  G               A 5' hsa-miR-3127-5p
            AGGG  AG     UGUUCGGGACU    
            UCCC  UC     GCAGGCCCUGA    
target 5'  C        AGAAA           A 3' LRRC75A-AS1
Start: 430  End: 450
Energy: -32.8 kcal/mol
Align Score: 0.005769
miRNA  3' GA    UA  G               A 5' hsa-miR-3127-5p
            AGGG  AG     UGUUCGGGACU    
            UCCC  UC     GCAGGCCCUGA    
target 5'  C        AGAAA           A 3' LRRC75A-AS1
Start: 254  End: 274
Energy: -32.8 kcal/mol
Align Score: 0.004836
miRNA  3 GA    UA  G               A 5 hsa-miR-3127-5p
            AGGG  AG     UGUUCGGGACU    
            UCCC  UC     GCAGGCCCUGA    
target 5  C        AGAAA           A 3 LRRC75A-AS1
Start: 430  End: 450
Energy: -32.8 kcal/mol
Align Score: 0.005769
miRNA  3 GA    UA  G               A 5 hsa-miR-3127-5p
            AGGG  AG     UGUUCGGGACU    
            UCCC  UC     GCAGGCCCUGA    
target 5  C        AGAAA           A 3 LRRC75A-AS1
Start: 254  End: 274
Energy: -32.8 kcal/mol
Align Score: 0.004836

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for LRRC75A-AS1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-3127-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for PHLPP1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 17p11.2

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.