Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

11q13.1

lncRNA

MALAT1 ( ENSG00000251562)

miRNA

hsa-miR-503-5p (MIMAT0002874)

mRNA

FGF2 (ENSG00000138685)

Disease

SKCM

FDR

1.26E-3

Reported as biomarkers
24

Circulating
20

Drug resistent
83

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' gaCGUCUUGACA-----AGGGCGACGAu 5' hsa-miR-503-5p
            |||| |||||     |||||||||| 
target 5' atGCAGTACTGTTCTGATCCCGCTGCTa 3' MALAT1
Start: 6623  End: 6650
Energy: -36.46 kcal/mol
Align Score: 172
miRNA  3' gaCGUCUUGACA-----AGGGCGACGAu 5' hsa-miR-503-5p
            |||| |||||     |||||||||| 
target 5' atGCAGTACTGTTCTGATCCCGCTGCTa 3' MALAT1
Start: 493  End: 520
Energy: -36.46 kcal/mol
Align Score: 172
miRNA  3' gaCGUCUUGACA-----AGGGCGACGAu 5' hsa-miR-503-5p
            |||| |||||     |||||||||| 
target 5' atGCAGTACTGTTCTGATCCCGCTGCTa 3' MALAT1
Start: 254  End: 281
Energy: -36.46 kcal/mol
Align Score: 172
miRNA  3' gaCGUCUUGACA-----AGGGCGACGAu 5' hsa-miR-503-5p
            |||| |||||     |||||||||| 
target 5' atGCAGTACTGTTCTGATCCCGCTGCTa 3' MALAT1
Start: 261  End: 288
Energy: -36.46 kcal/mol
Align Score: 172
TargetScan target site prediction
miRNA  3' GACGUCUUGACAAGG-----GCGACGAU 5' hsa-miR-503-5p
                 |||||||      ||||||| 
target 5'      GUACUGUUCUGAUCCCGCUGCUA MALAT1
Start: 513  End: 520
Site type: 8mer-1a
Context++ Score: -0.508
miRNA  3' GACGUCUUGACAAGG-----GCGACGAU 5' hsa-miR-503-5p
                 |||||||      ||||||| 
target 5'      GUACUGUUCUGAUCCCGCUGCUA MALAT1
Start: 274  End: 281
Site type: 8mer-1a
Context++ Score: -0.508
miRNA  3' GACGUCUUGACAAGG-----GCGACGAU 5' hsa-miR-503-5p
                 |||||||      ||||||| 
target 5'      GUACUGUUCUGAUCCCGCUGCUA MALAT1
Start: 281  End: 288
Site type: 8mer-1a
Context++ Score: -0.45
miRNA  3' GACGUCUUGACAAGG-----GCGACGAU 5' hsa-miR-503-5p
                 |||||||      ||||||| 
target 5'      GUACUGUUCUGAUCCCGCUGCUA MALAT1
Start: 513  End: 520
Site type: 8mer-1a
Context++ Score: -0.508
miRNA  3' GACGUCUUGACAAGG-----GCGACGAU 5' hsa-miR-503-5p
                 |||||||      ||||||| 
target 5'      GUACUGUUCUGAUCCCGCUGCUA MALAT1
Start: 274  End: 281
Site type: 8mer-1a
Context++ Score: -0.508
RNAbybrid target site prediction
miRNA  3' G                  A    U 5' hsa-miR-503-5p
           ACGUCUUG ACAAGGGCG  CGA    
           UGUAGGAC UGUUCCUGU  GCU    
target 5' U        U         GG   U 3' MALAT1
Start: 1258  End: 1278
Energy: -33.4 kcal/mol
Align Score: 0.009835
miRNA  3' G     U                       5' hsa-miR-503-5p
           ACGUC UGACA     AGGGCGACGAU    
           UGCAG ACUGU     UCCCGCUGCUA    
target 5' A     U     UCUGA           U 3' MALAT1
Start: 493  End: 513
Energy: -40.8 kcal/mol
Align Score: 0.000188
miRNA  3' G     U                       5' hsa-miR-503-5p
           ACGUC UGACA     AGGGCGACGAU    
           UGCAG ACUGU     UCCCGCUGCUA    
target 5' A     U     UCUGA           U 3' MALAT1
Start: 254  End: 274
Energy: -40.8 kcal/mol
Align Score: 0.000074
miRNA  3' G     U                       5' hsa-miR-503-5p
           ACGUC UGACA     AGGGCGACGAU    
           UGCAG ACUGU     UCCCGCUGCUA    
target 5' A     U     UCUGA           U 3' MALAT1
Start: 261  End: 281
Energy: -40.8 kcal/mol
Align Score: 0.000274
miRNA  3 G                  A    U 5 hsa-miR-503-5p
           ACGUCUUG ACAAGGGCG  CGA    
           UGUAGGAC UGUUCCUGU  GCU    
target 5 U        U         GG   U 3 MALAT1
Start: 1258  End: 1278
Energy: -33.4 kcal/mol
Align Score: 0.009835

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MALAT1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-503-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for FGF2

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 11q13.1

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.