Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

11q13.1

lncRNA

MALAT1 ( ENSG00000251562)

miRNA

hsa-miR-125a-3p (MIMAT0004602)

mRNA

BRCA1 (ENSG00000012048)

Disease

THCA

FDR

2.31E-2

Reported as biomarkers
24

Circulating
20

Drug resistent
83

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3     AG                UG   A 5 hsa-miR-125a-3p
           CCG  GGU     UCUUGGAG  GAC    
           GGC  CCA     GGGGCUUC  CUG    
target 5 A   AG   GCGCA        UG   A 3 MALAT1
Start: 12  End: 32
Energy: -30.7 kcal/mol
Align Score: 0.004251
miRNA  3     AG                UG   A 5 hsa-miR-125a-3p
           CCG  GGU     UCUUGGAG  GAC    
           GGC  CCA     GGGGCUUC  CUG    
target 5 A   AG   GCGCA        UG   A 3 MALAT1
Start: 12  End: 32
Energy: -30.7 kcal/mol
Align Score: 0.004948
miRNA  3     AG                UG   A 5 hsa-miR-125a-3p
           CCG  GGU     UCUUGGAG  GAC    
           GGC  CCA     GGGGCUUC  CUG    
target 5 A   AG   GCGCA        UG   A 3 MALAT1
Start: 12  End: 32
Energy: -30.7 kcal/mol
Align Score: 0.006398
miRNA  3                               U       5 hsa-miR-125a-3p
           CCGAG            GGU UCUUGGAG GGACA    
           GGCUU            CCA GGAGCCUU CCUGU    
target 5 A     AAAGUAGGACAA   U              G 3 MALAT1
Start: 7  End: 27
Energy: -29.1 kcal/mol
Align Score: 0.007034
miRNA  3 CCG                                 A 5 hsa-miR-125a-3p
             AGGGUUCU               UGGAGUGGAC    
             UCCUAAGG               GCCUCACCUG    
target 5   A        UCAAGAGAAGUGUCA          A 3 MALAT1
Start: 65  End: 85
Energy: -32.8 kcal/mol
Align Score: 0.003787

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MALAT1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-125a-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for BRCA1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 11q13.1

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.