Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

2q13

lncRNA

MIR4435-2HG ( ENSG00000172965)

miRNA

hsa-miR-138-5p (MIMAT0000430)

mRNA

TWIST2 (ENSG00000233608)

Disease

THCA

FDR

2.18E-3

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'  GCCGGACUAAGUGUUGUGGUCGA 5' hsa-miR-138-5p
                          ||||||| 
target 5'  AGCAAAGGCUGCAGUCACCAGCA MIR4435-2HG
Start: 196  End: 203
Site type: 8mer-1a
Context++ Score: -0.41
miRNA  3'  GCCGGACUAAGUGUUGUGGUCGA 5' hsa-miR-138-5p
                          ||||||| 
target 5'  AGCAAAGGCUGCAGUCACCAGCA MIR4435-2HG
Start: 196  End: 203
Site type: 8mer-1a
Context++ Score: -0.41
miRNA  3'  GCCGGACUAAGUGUUGUGGUCGA 5' hsa-miR-138-5p
                          ||||||| 
target 5'  AGCAAAGGCUGCAGUCACCAGCA MIR4435-2HG
Start: 181  End: 188
Site type: 8mer-1a
Context++ Score: -0.414
miRNA  3'  GCCGGACUAAGUGUUGUGGUCGA 5' hsa-miR-138-5p
                          ||||||| 
target 5'  AGCAAAGGCUGCAGUCACCAGCA MIR4435-2HG
Start: 202  End: 209
Site type: 8mer-1a
Context++ Score: -0.408
RNAbybrid target site prediction
miRNA  3 G          U    UG U      A 5 hsa-miR-138-5p
           CCGGACUAAG GUUG  G     CG    
           GGCCUGGUUC CAAC  C     GU    
target 5 G               UG CCACU  G 3 MIR4435-2HG
Start: 344  End: 364
Energy: -32 kcal/mol
Align Score: 0.004501
miRNA  3 G          U    UG U      A 5 hsa-miR-138-5p
           CCGGACUAAG GUUG  G     CG    
           GGCCUGGUUC CAAC  C     GU    
target 5 G               UG CCACU  G 3 MIR4435-2HG
Start: 610  End: 630
Energy: -32 kcal/mol
Align Score: 0.007516
miRNA  3 G          U    UG U      A 5 hsa-miR-138-5p
           CCGGACUAAG GUUG  G     CG    
           GGCCUGGUUC CAAC  C     GU    
target 5 G               UG CCACU  G 3 MIR4435-2HG
Start: 392  End: 412
Energy: -32 kcal/mol
Align Score: 0.004933
miRNA  3 G          U    UG U      A 5 hsa-miR-138-5p
           CCGGACUAAG GUUG  G     CG    
           GGCCUGGUUC CAAC  C     GU    
target 5 G               UG CCACU  G 3 MIR4435-2HG
Start: 256  End: 276
Energy: -32 kcal/mol
Align Score: 0.003366
miRNA  3 G          U    UG U      A 5 hsa-miR-138-5p
           CCGGACUAAG GUUG  G     CG    
           GGCCUGGUUC CAAC  C     GU    
target 5 G               UG CCACU  G 3 MIR4435-2HG
Start: 602  End: 622
Energy: -32 kcal/mol
Align Score: 0.00731

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MIR4435-2HG

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-138-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for TWIST2

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 2q13

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.