Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

1q25.1

lncRNA

GAS5 ( ENSG00000234741)

miRNA

hsa-miR-18b-5p (MIMAT0001412)

mRNA

ESR1 (ENSG00000091831)

Disease

THCA

FDR

5.00E-8

Reported as biomarkers
18

Circulating
9

Drug resistent
39

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' gauugaCGUGAUCUA-CGUGGAAu 5' hsa-miR-18b-5p
                || ||:||| ||||||| 
target 5' agtgtgGCTCTGGATAGCACCTTa 3' GAS5
Start: 53  End: 76
Energy: -23.89 kcal/mol
Align Score: 164
miRNA  3' gauugaCGUGAUCUA-CGUGGAAu 5' hsa-miR-18b-5p
                || ||:||| ||||||| 
target 5' agtgtgGCTCTGGATAGCACCTTa 3' GAS5
Start: 23  End: 46
Energy: -23.89 kcal/mol
Align Score: 164
miRNA  3' gauugaCGUGAUCUA-CGUGGAAu 5' hsa-miR-18b-5p
                || ||:||| ||||||| 
target 5' agtgtgGCTCTGGATAGCACCTTa 3' GAS5
Start: 23  End: 46
Energy: -23.89 kcal/mol
Align Score: 164
miRNA  3' gauugaCGUGAUCUA-CGUGGAAu 5' hsa-miR-18b-5p
                || ||:||| ||||||| 
target 5' agtgtgGCTCTGGATAGCACCTTa 3' GAS5
Start: 23  End: 46
Energy: -23.89 kcal/mol
Align Score: 164
miRNA  3' gauugaCGUGAUCUA-CGUGGAAu 5' hsa-miR-18b-5p
                || ||:||| ||||||| 
target 5' agtgtgGCTCTGGATAGCACCTTa 3' GAS5
Start: 47  End: 70
Energy: -23.89 kcal/mol
Align Score: 164
TargetScan target site prediction
miRNA  3'  GAUUGACGUGAUCUACGUGGAAU 5' hsa-miR-18b-5p
                          ||||||| 
target 5'  GUGUGGCUCUGGAUAGCACCUUA GAS5
Start: 69  End: 76
Site type: 8mer-1a
Context++ Score: -0.417
miRNA  3'  GAUUGACGUGAUCUACGUGGAAU 5' hsa-miR-18b-5p
                          ||||||| 
target 5'  GUGUGGCUCUGGAUAGCACCUUA GAS5
Start: 39  End: 46
Site type: 8mer-1a
Context++ Score: -0.424
miRNA  3'  GAUUGACGUGAUCUACGUGGAAU 5' hsa-miR-18b-5p
                          ||||||| 
target 5'  GUGUGGCUCUGGAUAGCACCUUA GAS5
Start: 39  End: 46
Site type: 8mer-1a
Context++ Score: -0.424
miRNA  3'  GAUUGACGUGAUCUACGUGGAAU 5' hsa-miR-18b-5p
                          ||||||| 
target 5'  GUGUGGCUCUGGAUAGCACCUUA GAS5
Start: 39  End: 46
Site type: 8mer-1a
Context++ Score: -0.424
miRNA  3'  GAUUGACGUGAUCUACGUGGAAU 5' hsa-miR-18b-5p
                          ||||||| 
target 5'  GUGUGGCUCUGGAUAGCACCUUA GAS5
Start: 63  End: 70
Site type: 8mer-1a
Context++ Score: -0.418
RNAbybrid target site prediction
miRNA  3'      G                                   5' hsa-miR-18b-5p
           GAUU ACGU              GAUCUA CGUGGAAU    
           CUGG UGCA              CUGGAU GCACCUUA    
target 5' G    G    GAUGCAGUGUGGCU      A        U 3' GAS5
Start: 5  End: 25
Energy: -29.4 kcal/mol
Align Score: 0.0045
miRNA  3      G                                   5 hsa-miR-18b-5p
           GAUU ACGU              GAUCUA CGUGGAAU    
           CUGG UGCA              CUGGAU GCACCUUA    
target 5 G    G    GAUGCAGUGUGGCU      A        U 3 GAS5
Start: 5  End: 25
Energy: -29.4 kcal/mol
Align Score: 0.0045

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for GAS5

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-18b-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for ESR1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 1q25.1

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.