Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

2q13

lncRNA

MIR4435-2HG ( ENSG00000172965)

miRNA

hsa-miR-296-5p (MIMAT0000690)

mRNA

DLL4 (ENSG00000128917)

Disease

THCA

FDR

4.80E-3

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'     UGUCCUAACUCCCCCCCGGGA 5' hsa-miR-296-5p
                           ||||||| 
target 5'   CUUCUGAGCUAUGAAGGGGCCCA MIR4435-2HG
Start: 200  End: 207
Site type: 8mer-1a
Context++ Score: -0.618
RNAbybrid target site prediction
miRNA  3             CC            5 hsa-miR-296-5p
           UGUC CUAACU  CCCCCG GGA    
           GCAG GGUUGA  GGGGGC CCU    
target 5 G    A      A       U   C 3 MIR4435-2HG
Start: 199  End: 219
Energy: -33.9 kcal/mol
Align Score: 0.003354
miRNA  3      CUAA                GA 5 hsa-miR-296-5p
           UGUC    CUCCC     CCCCGG     
           GCAG    GAGGG     GGGGCC     
target 5 C    UG       CCACU      G  3 MIR4435-2HG
Start: 204  End: 224
Energy: -30.9 kcal/mol
Align Score: 0.006669
miRNA  3        A                          A 5 hsa-miR-296-5p
           UGUCCU   AC UCCCC          CCCGGG    
           ACAGGG   UG AGGGG          GGGCCC    
target 5 A      GCA  U     AAGAGCCUCA      A 3 MIR4435-2HG
Start: 922  End: 942
Energy: -35.2 kcal/mol
Align Score: 0.00505
miRNA  3             CC            5 hsa-miR-296-5p
           UGUC CUAACU  CCCCCG GGA    
           GCAG GGUUGA  GGGGGC CCU    
target 5 G    A      A       U   C 3 MIR4435-2HG
Start: 125  End: 145
Energy: -33.9 kcal/mol
Align Score: 0.002095
miRNA  3             CC            5 hsa-miR-296-5p
           UGUC CUAACU  CCCCCG GGA    
           GCAG GGUUGA  GGGGGC CCU    
target 5 G    A      A       U   C 3 MIR4435-2HG
Start: 125  End: 145
Energy: -33.9 kcal/mol
Align Score: 0.002967

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MIR4435-2HG

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-296-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for DLL4

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 2q13

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.