Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

17q21.32

lncRNA

HOXB-AS3 ( ENSG00000233101)

miRNA

hsa-miR-331-3p (MIMAT0000760)

mRNA

PHLPP1 (ENSG00000081913)

Disease

TGCT

FDR

2.43E-2

Reported as biomarkers
0

Circulating
0

Drug resistent
1

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'     AAGAUCCUAUCCGGGUCCCCG 5' hsa-miR-331-3p
                           ||||||| 
target 5'   UCUAAGCCCAGAGGUCCAGGGGA HOXB-AS3
Start: 272  End: 279
Site type: 8mer-1a
Context++ Score: -0.414
miRNA  3'     AAGAUCCUAUCCGGGUCCCCG 5' hsa-miR-331-3p
                           ||||||| 
target 5'   UCUAAGCCCAGAGGUCCAGGGGA HOXB-AS3
Start: 250  End: 257
Site type: 8mer-1a
Context++ Score: -0.417
miRNA  3'     AAGAUCCUAUCCGGGUCCCCG 5' hsa-miR-331-3p
                           ||||||| 
target 5'   UCUAAGCCCAGAGGUCCAGGGGA HOXB-AS3
Start: 266  End: 273
Site type: 8mer-1a
Context++ Score: -0.413
miRNA  3'     AAGAUCCUAUCCGGGUCCCCG 5' hsa-miR-331-3p
                           ||||||| 
target 5'   UCUAAGCCCAGAGGUCCAGGGGA HOXB-AS3
Start: 246  End: 253
Site type: 8mer-1a
Context++ Score: -0.418
RNAbybrid target site prediction
miRNA  3 A               G              5 hsa-miR-331-3p
           AGAUC CUAUC CGG      UC CCCG    
           UCUGG GAUGG GCC      GG GGGC    
target 5 G     A     A   ACUACA  C    C 3 HOXB-AS3
Start: 85  End: 105
Energy: -31.1 kcal/mol
Align Score: 0.004523
miRNA  3 A    CCUA              G 5 hsa-miR-331-3p
           AGAU       UCCGGGUCCCC    
           UCUA       AGGUCCAGGGG    
target 5 A    AGCCCAG           A 3 HOXB-AS3
Start: 256  End: 276
Energy: -31.2 kcal/mol
Align Score: 0.005772
miRNA  3 A    CCUA              G 5 hsa-miR-331-3p
           AGAU       UCCGGGUCCCC    
           UCUA       AGGUCCAGGGG    
target 5 A    AGCCCAG           A 3 HOXB-AS3
Start: 234  End: 254
Energy: -31.2 kcal/mol
Align Score: 0.008544
miRNA  3 A               G              5 hsa-miR-331-3p
           AGAUC CUAUC CGG      UC CCCG    
           UCUGG GAUGG GCC      GG GGGC    
target 5 G     A     A   ACUACA  C    C 3 HOXB-AS3
Start: 117  End: 137
Energy: -31.1 kcal/mol
Align Score: 0.005039
miRNA  3 A               G              5 hsa-miR-331-3p
           AGAUC CUAUC CGG      UC CCCG    
           UCUGG GAUGG GCC      GG GGGC    
target 5 G     A     A   ACUACA  C    C 3 HOXB-AS3
Start: 81  End: 101
Energy: -31.1 kcal/mol
Align Score: 0.004536

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for HOXB-AS3

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-331-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for PHLPP1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 17q21.32

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.