Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

10q26.11

lncRNA

CASC2 ( ENSG00000177640)

miRNA

hsa-miR-149-5p (MIMAT0000450)

mRNA

GPC1 (ENSG00000063660)

Disease

THYM

FDR

3.07E-3

Reported as biomarkers
0

Circulating
1

Drug resistent
14

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' ccCUCA-CUUCUGUGCCUCGGUCu 5' hsa-miR-149-5p
            |:|| ||||: |: ||||||| 
target 5' aaGGGTAGAAGGAAT-GAGCCAGc 3' CASC2
Start: 397  End: 419
Energy: -25.06 kcal/mol
Align Score: 162
TargetScan target site prediction
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
               ||||       ||||||| 
target 5'  UGCAUGAAUUUCUAAGAGCCAGA CASC2
Start: 541  End: 548
Site type: 8mer-1a
Context++ Score: -0.507
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
               ||||       ||||||| 
target 5'  UGCAUGAAUUUCUAAGAGCCAGA CASC2
Start: 452  End: 459
Site type: 8mer-1a
Context++ Score: -0.426
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
               ||||       ||||||| 
target 5'  UGCAUGAAUUUCUAAGAGCCAGA CASC2
Start: 252  End: 259
Site type: 8mer-1a
Context++ Score: -0.477
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
               ||||       ||||||| 
target 5'  UGCAUGAAUUUCUAAGAGCCAGA CASC2
Start: 541  End: 548
Site type: 8mer-1a
Context++ Score: -0.507
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
               ||||       ||||||| 
target 5'  UGCAUGAAUUUCUAAGAGCCAGA CASC2
Start: 452  End: 459
Site type: 8mer-1a
Context++ Score: -0.426
RNAbybrid target site prediction
miRNA  3'                             C       5' hsa-miR-149-5p
           CCCU   CACUUC       UGUGCCU GGUCU    
           GGGG   GUGAGG       ACACGGA CCGGG    
target 5' C    CAC      CCUGGCC       C     C 3' CASC2
Start: 180  End: 200
Energy: -32.3 kcal/mol
Align Score: 0.005699
miRNA  3                             C       5 hsa-miR-149-5p
           CCCU   CACUUC       UGUGCCU GGUCU    
           GGGG   GUGAGG       ACACGGA CCGGG    
target 5 C    CAC      CCUGGCC       C     C 3 CASC2
Start: 180  End: 200
Energy: -32.3 kcal/mol
Align Score: 0.005699

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for CASC2

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-149-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for GPC1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 10q26.11

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.