Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

17q21.32

lncRNA

HOXB-AS3 ( ENSG00000233101)

miRNA

hsa-miR-615-3p (MIMAT0003283)

mRNA

LCOR (ENSG00000196233)

Disease

THYM

FDR

7.05E-5

Reported as biomarkers
0

Circulating
0

Drug resistent
1

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'   UUCUCCCUCUGGGUCCGAGCCU 5' hsa-miR-615-3p
                ||||      ||||||| 
target 5' GAGAGCGGGAAGAGA-GGCUCGGA HOXB-AS3
Start: 282  End: 289
Site type: 8mer-1a
Context++ Score: -0.529
miRNA  3'   UUCUCCCUCUGGGUCCGAGCCU 5' hsa-miR-615-3p
                ||||      ||||||| 
target 5' GAGAGCGGGAAGAGA-GGCUCGGA HOXB-AS3
Start: 214  End: 221
Site type: 8mer-1a
Context++ Score: -0.529
miRNA  3'   UUCUCCCUCUGGGUCCGAGCCU 5' hsa-miR-615-3p
                ||||      ||||||| 
target 5' GAGAGCGGGAAGAGA-GGCUCGGA HOXB-AS3
Start: 308  End: 315
Site type: 8mer-1a
Context++ Score: -0.529
miRNA  3'   UUCUCCCUCUGGGUCCGAGCCU 5' hsa-miR-615-3p
                ||||      ||||||| 
target 5' GAGAGCGGGAAGAGA-GGCUCGGA HOXB-AS3
Start: 264  End: 271
Site type: 8mer-1a
Context++ Score: -0.529
miRNA  3'   UUCUCCCUCUGGGUCCGAGCCU 5' hsa-miR-615-3p
                ||||      ||||||| 
target 5' GAGAGCGGGAAGAGA-GGCUCGGA HOXB-AS3
Start: 197  End: 204
Site type: 8mer-1a
Context++ Score: -0.532
RNAbybrid target site prediction
miRNA  3 UUC   C          A        5 hsa-miR-615-3p
             UCC UCUGGGUCCG   GCCU    
             AGG GGGCCUGGGC   UGGA    
target 5   C   C          GCC    G 3 HOXB-AS3
Start: 105  End: 125
Energy: -30.6 kcal/mol
Align Score: 0.005842
miRNA  3 U                          G  U 5 hsa-miR-615-3p
           UCUCCC     UCUGGG    UCCGA CC    
           AGAGGG     GGACCU    GGGCU GG    
target 5 C      GCCAA      UCUA        C 3 HOXB-AS3
Start: 365  End: 385
Energy: -31 kcal/mol
Align Score: 0.006605
miRNA  3 U                          G  U 5 hsa-miR-615-3p
           UCUCCC     UCUGGG    UCCGA CC    
           AGAGGG     GGACCU    GGGCU GG    
target 5 C      GCCAA      UCUA        C 3 HOXB-AS3
Start: 343  End: 363
Energy: -31 kcal/mol
Align Score: 0.009715
miRNA  3       C    GGG            5 hsa-miR-615-3p
           UUCUC CUCU    UCCGAGCCU    
           GAGAG GGGA    AGGCUCGGA    
target 5 A     C    AGAG         G 3 HOXB-AS3
Start: 266  End: 286
Energy: -33.2 kcal/mol
Align Score: 0.002551
miRNA  3 UUC   C          A        5 hsa-miR-615-3p
             UCC UCUGGGUCCG   GCCU    
             AGG GGGCCUGGGC   UGGA    
target 5   C   C          GCC    G 3 HOXB-AS3
Start: 137  End: 157
Energy: -30.6 kcal/mol
Align Score: 0.00649

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for HOXB-AS3

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-615-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for LCOR

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 17q21.32

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.