Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

21q22.11

lncRNA

LINC00649 ( ENSG00000237945)

miRNA

hsa-miR-1291 (MIMAT0005881)

mRNA

ERN1 (ENSG00000178607)

Disease

BRCA

FDR

3.74E-37

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3' UGACGACCAGAAGUCA--GUCCCGGU 5' hsa-miR-1291
                   |||      ||||||| 
target 5'    AGGUUCCUUGAGAUCCAGGGCCA LINC00649
Start: 136  End: 143
Site type: 8mer-1a
Context++ Score: -0.474
miRNA  3' UGACGACCAGAAGUCA--GUCCCGGU 5' hsa-miR-1291
                   |||      ||||||| 
target 5'    AGGUUCCUUGAGAUCCAGGGCCA LINC00649
Start: 279  End: 286
Site type: 8mer-1a
Context++ Score: -0.445
RNAbybrid target site prediction
miRNA  3    A  A        G  A            5 hsa-miR-1291
           UG CG CCA  GAA UC   GUCCCGGU    
           GC GC GGU  CUU AG   CAGGGCCA    
target 5 G  G  A   UC   G  AUC        U 3 LINC00649
Start: 115  End: 135
Energy: -32.1 kcal/mol
Align Score: 0.006893
miRNA  3 U          A     A               GU 5 hsa-miR-1291
           GACGAC CAG  AGUC         GUC CCG     
           UUGCUG GUC  UCGG         CAG GGC     
target 5 C      U   CC    GCUGGAGUG   U   A  3 LINC00649
Start: 58  End: 78
Energy: -27.9 kcal/mol
Align Score: 0.00673
miRNA  3 UGAC      AA     A             5 hsa-miR-1291
              GACCAG    GUC G   UCCCGGU    
              CUGGUC    CGG C   GGGGCCA    
target 5    A      AUCC   C UCU       U 3 LINC00649
Start: 185  End: 205
Energy: -29.2 kcal/mol
Align Score: 0.005794
miRNA  3    A  A        G  A            5 hsa-miR-1291
           UG CG CCA  GAA UC   GUCCCGGU    
           GC GC GGU  CUU AG   CAGGGCCA    
target 5 G  G  A   UC   G  AUC        U 3 LINC00649
Start: 258  End: 278
Energy: -32.1 kcal/mol
Align Score: 0.008202

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for LINC00649

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-1291

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for ERN1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 21q22.11

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.