Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

1p22.1

lncRNA

CCDC18-AS1 ( ENSG00000223745)

miRNA

hsa-miR-185-3p (MIMAT0004611)

mRNA

AKT1 (ENSG00000142208)

Disease

BRCA

FDR

1.07E-4

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'  CUGGUCUCCUUUCGGUCGGGGA 5' hsa-miR-185-3p
                  ||||   ||||||| 
target 5' CCUGCUGUGGAAGACCAGCCCCA CCDC18-AS1
Start: 270  End: 277
Site type: 8mer-1a
Context++ Score: -0.471
miRNA  3'  CUGGUCUCCUUUCGGUCGGGGA 5' hsa-miR-185-3p
                  ||||   ||||||| 
target 5' CCUGCUGUGGAAGACCAGCCCCA CCDC18-AS1
Start: 351  End: 358
Site type: 8mer-1a
Context++ Score: -0.472
miRNA  3'  CUGGUCUCCUUUCGGUCGGGGA 5' hsa-miR-185-3p
                  ||||   ||||||| 
target 5' CCUGCUGUGGAAGACCAGCCCCA CCDC18-AS1
Start: 998  End: 1005
Site type: 8mer-1a
Context++ Score: -0.456
miRNA  3'  CUGGUCUCCUUUCGGUCGGGGA 5' hsa-miR-185-3p
                  ||||   ||||||| 
target 5' CCUGCUGUGGAAGACCAGCCCCA CCDC18-AS1
Start: 312  End: 319
Site type: 8mer-1a
Context++ Score: -0.472
miRNA  3'  CUGGUCUCCUUUCGGUCGGGGA 5' hsa-miR-185-3p
                  ||||   ||||||| 
target 5' CCUGCUGUGGAAGACCAGCCCCA CCDC18-AS1
Start: 166  End: 173
Site type: 8mer-1a
Context++ Score: -0.473
RNAbybrid target site prediction
miRNA  3      U    U     C        A 5 hsa-miR-185-3p
           CUGG    C CCUUU GGUCGGGG    
           GGCC    G GGAAG CCAGCCCC    
target 5 G    UGCU U     A        A 3 CCDC18-AS1
Start: 252  End: 272
Energy: -35.5 kcal/mol
Align Score: 0.000805
miRNA  3      U    U     C        A 5 hsa-miR-185-3p
           CUGG    C CCUUU GGUCGGGG    
           GGCC    G GGAAG CCAGCCCC    
target 5 G    UGCU U     A        A 3 CCDC18-AS1
Start: 333  End: 353
Energy: -35.5 kcal/mol
Align Score: 0.001036
miRNA  3      U    U     C        A 5 hsa-miR-185-3p
           CUGG    C CCUUU GGUCGGGG    
           GGCC    G GGAAG CCAGCCCC    
target 5 G    UGCU U     A        A 3 CCDC18-AS1
Start: 980  End: 1000
Energy: -35.5 kcal/mol
Align Score: 0.003493
miRNA  3      U    U     C        A 5 hsa-miR-185-3p
           CUGG    C CCUUU GGUCGGGG    
           GGCC    G GGAAG CCAGCCCC    
target 5 G    UGCU U     A        A 3 CCDC18-AS1
Start: 294  End: 314
Energy: -35.5 kcal/mol
Align Score: 0.00091
miRNA  3      U    U     C        A 5 hsa-miR-185-3p
           CUGG    C CCUUU GGUCGGGG    
           GGCC    G GGAAG CCAGCCCC    
target 5 G    UGCU U     A        A 3 CCDC18-AS1
Start: 148  End: 168
Energy: -35.5 kcal/mol
Align Score: 0.000483

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for CCDC18-AS1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-185-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for AKT1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 1p22.1

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.