Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

8q24.21

lncRNA

PVT1 ( ENSG00000249859)

miRNA

hsa-miR-27a-5p (MIMAT0004501)

mRNA

RUNX2 (ENSG00000124813)

Disease

BRCA

FDR

1.89E-31

Reported as biomarkers
11

Circulating
6

Drug resistent
51

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3 A    U         C           A 5 hsa-miR-27a-5p
           CGAG    GUUCGU    GAUUCGGG    
           GCUU    CAAGUA    CUGAGCCU    
target 5 A    CGUU      UUUU        G 3 PVT1
Start: 139  End: 159
Energy: -27.5 kcal/mol
Align Score: 0.008331
miRNA  3 A   G G                             5 hsa-miR-27a-5p
           CGA U U          UCGUCGAU  UCGGGA    
           GCU A G          AGCAGCUG  GGCCUU    
target 5 C   G G UGGAUGGAGA        GG      G 3 PVT1
Start: 112  End: 132
Energy: -28.3 kcal/mol
Align Score: 0.003901
miRNA  3 A           G     U             A 5 hsa-miR-27a-5p
           CGAGUG  UUC UCGAU          CGGG    
           GUUCAU  GAG AGCUG          GCCC    
target 5 G      CU   G     CAUCUACCCU    A 3 PVT1
Start: 29  End: 49
Energy: -27.5 kcal/mol
Align Score: 0.003096

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for PVT1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-27a-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for RUNX2

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 8q24.21

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.