Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

14q32.2

lncRNA

MEG3 ( ENSG00000214548)

miRNA

hsa-miR-370-3p (MIMAT0000722)

mRNA

CTNNB1 (ENSG00000168036)

Disease

BRCA

FDR

6.53E-5

Reported as biomarkers
9

Circulating
15

Drug resistent
23

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3 U G    A        G                       5 hsa-miR-370-3p
           G UCCA      GGU GGGUCG           UCCG    
           U GGGU      CCA CCCAGC           GGGC    
target 5 G G    GUCCUG   G      CCCGUCACCAC    U 3 MEG3
Start: 111  End: 131
Energy: -32.2 kcal/mol
Align Score: 0.005136
miRNA  3 UG                            U  U     5 hsa-miR-370-3p
            GUCCAAGG               UGGGG CG CCG    
            CAGGUUCC               GCCCC GC GGU    
target 5  G        CAGUGCCCCCGACAA     U  U   G 3 MEG3
Start: 1039  End: 1059
Energy: -35.4 kcal/mol
Align Score: 0.00418
miRNA  3 UG                            U  U     5 hsa-miR-370-3p
            GUCCAAGG               UGGGG CG CCG    
            CAGGUUCC               GCCCC GC GGU    
target 5  A        CAGUGCCCCCGACAA     U  U   G 3 MEG3
Start: 974  End: 994
Energy: -35.7 kcal/mol
Align Score: 0.004649
miRNA  3        A  G    GU            5 hsa-miR-370-3p
           UGGUCC AG UGGG  CGU    CCG    
           GCCGGG UC GCCU  GCG    GGC    
target 5 G      G  G    UU   CCGU   U 3 MEG3
Start: 65  End: 85
Energy: -32 kcal/mol
Align Score: 0.004086
miRNA  3            AA                        5 hsa-miR-370-3p
           UGGU    CC  GGU        GGGGUCGUCCG    
           ACCA    GG  CCA        UCCUGGCGGGC    
target 5 C    UCCC  AC   AGUCUUCU           C 3 MEG3
Start: 342  End: 362
Energy: -30.8 kcal/mol
Align Score: 0.005846

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MEG3

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-370-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for CTNNB1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 14q32.2

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.