Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

12q13.13

lncRNA

HOTAIR ( ENSG00000228630)

miRNA

hsa-miR-423-3p (MIMAT0001340)

mRNA

PA2G4 (ENSG00000170515)

Disease

ESCA

FDR

1.30E-2

Reported as biomarkers
43

Circulating
24

Drug resistent
100

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3 U             A          C      5 hsa-miR-423-3p
           GACU  CCC CGG    GUC UGG UCGA    
           CUGA  GGG GCC    CAG ACC GGCU    
target 5 C    GC   U   GGGG   C   C    C 3 HOTAIR
Start: 868  End: 888
Energy: -31.8 kcal/mol
Align Score: 0.009808
miRNA  3     CU                      C    5 hsa-miR-423-3p
           UGA    CCCCGGA    GUC UGGCU GA    
           GCU    GGGGCCU    CAG ACCGA CU    
target 5 A   CGUU       AAGC   U     C  G 3 HOTAIR
Start: 248  End: 268
Energy: -31.5 kcal/mol
Align Score: 0.006228
miRNA  3     CU                      C    5 hsa-miR-423-3p
           UGA    CCCCGGA    GUC UGGCU GA    
           GCU    GGGGCCU    CAG ACCGA CU    
target 5 A   CGUU       AAGC   U     C  G 3 HOTAIR
Start: 337  End: 357
Energy: -31.5 kcal/mol
Align Score: 0.006092
miRNA  3     CU                      C    5 hsa-miR-423-3p
           UGA    CCCCGGA    GUC UGGCU GA    
           GCU    GGGGCCU    CAG ACCGA CU    
target 5 A   CGUU       AAGC   U     C  G 3 HOTAIR
Start: 519  End: 539
Energy: -31.5 kcal/mol
Align Score: 0.006065

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for HOTAIR

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-423-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for PA2G4

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 12q13.13

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.