Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

12q24.31

lncRNA

LINC01089 ( ENSG00000212694)

miRNA

hsa-miR-1249-3p (MIMAT0005901)

mRNA

PTCH1 (ENSG00000185920)

Disease

LGG

FDR

1.78E-14

Reported as biomarkers
0

Circulating
0

Drug resistent
2

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
miRNA  3'  ACUUCUUCCCCCCCUUCCCGCA 5' hsa-miR-1249-3p
                         ||||||| 
target 5' UGCCUCUUCUGCCCCAAGGGCGA LINC01089
Start: 66  End: 73
Site type: 8mer-1a
Context++ Score: -0.417
RNAbybrid target site prediction
miRNA  3 A            CCUU      CA 5 hsa-miR-1249-3p
           CUUCUUCCCC C      CCCG     
           GGAGAAGGGG G      GGGC     
target 5 C          C ACGUUC    A  3 LINC01089
Start: 170  End: 190
Energy: -30.6 kcal/mol
Align Score: 0.006631
miRNA  3    UU  UC                  A 5 hsa-miR-1249-3p
           AC  CU  CCCCCCUU     CCCGC    
           UG  GG  GGGGGGAG     GGGUG    
target 5 U  GG  UU        CUGGU     A 3 LINC01089
Start: 344  End: 364
Energy: -35.1 kcal/mol
Align Score: 0.003408
miRNA  3 ACUUCUU              CA 5 hsa-miR-1249-3p
                 CC CCCCCUUCCCG     
                 GG GGGGGGAGGGC     
target 5       C  C           C  3 LINC01089
Start: 625  End: 645
Energy: -33.5 kcal/mol
Align Score: 0.005706
miRNA  3    UU  UC                  A 5 hsa-miR-1249-3p
           AC  CU  CCCCCCUU     CCCGC    
           UG  GG  GGGGGGAG     GGGUG    
target 5 U  GG  UU        CUGGU     A 3 LINC01089
Start: 546  End: 566
Energy: -35.1 kcal/mol
Align Score: 0.004297
miRNA  3 ACUUCUU              CA 5 hsa-miR-1249-3p
                 CC CCCCCUUCCCG     
                 GG GGGGGGAGGGC     
target 5       C  C           C  3 LINC01089
Start: 350  End: 370
Energy: -33.5 kcal/mol
Align Score: 0.002179

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for LINC01089

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-1249-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for PTCH1

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 12q24.31

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.