Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

14q32.2

lncRNA

MEG3 ( ENSG00000214548)

miRNA

hsa-miR-550a-5p (MIMAT0004800)

mRNA

RNF43 (ENSG00000108375)

Disease

LGG

FDR

5.01E-10

Reported as biomarkers
9

Circulating
15

Drug resistent
23

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' ccCGAGAAUGAGGGAGUCCGUGa 5' hsa-miR-550a-5p
            |||||  :| | |||||||| 
target 5' ggGCTCTCCTTGCATCAGGCACg 3' MEG3
Start: 900  End: 922
Energy: -30.87 kcal/mol
Align Score: 169
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3'           A           A                5' hsa-miR-550a-5p
           CCCGA  GA      UGAGGG       GUCCGUGA    
           GGGCU  CU      GCUCCC       CAGGCACU    
target 5' C     GC  CGAGCA      CCAGCAC        C 3' MEG3
Start: 144  End: 164
Energy: -33.4 kcal/mol
Align Score: 0.003476
miRNA  3'         AU   G          A 5' hsa-miR-550a-5p
           CCCGAGA  GAG G AGUCCGUG    
           GGGCUCU  CUU C UCAGGCAC    
target 5' C       C    G A        G 3' MEG3
Start: 899  End: 919
Energy: -36.1 kcal/mol
Align Score: 0.003642
miRNA  3'          AU                    GA 5' hsa-miR-550a-5p
           CCC GAGA   GAGGGAG       UCCGU     
           GGG CUCU   CUCCUUC       GGGCG     
target 5' C   C    CGU       CUGGUUU     G  3' MEG3
Start: 372  End: 392
Energy: -30.5 kcal/mol
Align Score: 0.006918
miRNA  3'          AU       A       UG   5' hsa-miR-550a-5p
           CCCGA GA    GAGGG   GUCCG  A    
           GGGCU CU    CUCCC   CGGGU  U    
target 5' U     G  GCUU     CAG     UG A 3' MEG3
Start: 51  End: 71
Energy: -33.4 kcal/mol
Align Score: 0.002581
miRNA  3           A           A                5 hsa-miR-550a-5p
           CCCGA  GA      UGAGGG       GUCCGUGA    
           GGGCU  CU      GCUCCC       CAGGCACU    
target 5 C     GC  CGAGCA      CCAGCAC        C 3 MEG3
Start: 144  End: 164
Energy: -33.4 kcal/mol
Align Score: 0.003476

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for MEG3

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-550a-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for RNF43

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 14q32.2

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.