Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

10p11.23

lncRNA

SVIL-AS1 ( ENSG00000224597)

miRNA

hsa-let-7b-5p (MIMAT0000063)

mRNA

NRAS (ENSG00000213281)

Disease

LUAD

FDR

8.45E-11

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' uugGUGUGUUGGAUGAUGGAGu 5' hsa-let-7b-5p
             |||| |  || ||||||| 
target 5' gagCACAGACACTTCTACCTCa 3' SVIL-AS1
Start: 347  End: 368
Energy: -23.58 kcal/mol
Align Score: 163
miRNA  3' uugGUGUGUUGGAUGAUGGAGu 5' hsa-let-7b-5p
             |||| |  || ||||||| 
target 5' gagCACAGACACTTCTACCTCa 3' SVIL-AS1
Start: 597  End: 618
Energy: -23.58 kcal/mol
Align Score: 163
miRNA  3' uugGUGUGUUGGAUGAUGGAGu 5' hsa-let-7b-5p
             |||| |  || ||||||| 
target 5' gagCACAGACACTTCTACCTCa 3' SVIL-AS1
Start: 344  End: 365
Energy: -23.58 kcal/mol
Align Score: 163
TargetScan target site prediction
miRNA  3' UUGGUGUGUUGGAU--GAUGGAGU 5' hsa-let-7b-5p
               ||||       ||||||| 
target 5'  AGAGCACAGACACUUCUACCUCA SVIL-AS1
Start: 358  End: 365
Site type: 8mer-1a
Context++ Score: -0.434
miRNA  3' UUGGUGUGUUGGAU--GAUGGAGU 5' hsa-let-7b-5p
               ||||       ||||||| 
target 5'  AGAGCACAGACACUUCUACCUCA SVIL-AS1
Start: 358  End: 365
Site type: 8mer-1a
Context++ Score: -0.434
RNAbybrid target site prediction
miRNA  3' U   U     UG             5' hsa-let-7b-5p
           UGG GUG U  GAUGAUGGAGU    
           GCC UGC G  CUACUGCCUCA    
target 5' U   C   U UG           G 3' SVIL-AS1
Start: 223  End: 243
Energy: -29.8 kcal/mol
Align Score: 0.009667
miRNA  3 U   U     UG             5 hsa-let-7b-5p
           UGG GUG U  GAUGAUGGAGU    
           GCC UGC G  CUACUGCCUCA    
target 5 U   C   U UG           G 3 SVIL-AS1
Start: 223  End: 243
Energy: -29.8 kcal/mol
Align Score: 0.009667

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for SVIL-AS1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-let-7b-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for NRAS

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 10p11.23

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.