Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

14q11.2

lncRNA

PRMT5-AS1 ( ENSG00000237054)

miRNA

hsa-miR-149-5p (MIMAT0000450)

mRNA

MTHFR (ENSG00000177000)

Disease

LUAD

FDR

8.70E-5

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
miRNA  3' ccCUCACUUCUGUG-CCUCGGUCu 5' hsa-miR-149-5p
            ||| ||||| |: |||||||| 
target 5' tgGAG-GAAGAGATGGGAGCCAGa 3' PRMT5-AS1
Start: 2307  End: 2329
Energy: -34.78 kcal/mol
Align Score: 170
miRNA  3' ccCUCACUUCUGUG-CCUCGGUCu 5' hsa-miR-149-5p
            ||| ||||| |: |||||||| 
target 5' tgGAG-GAAGAGATGGGAGCCAGa 3' PRMT5-AS1
Start: 708  End: 730
Energy: -34.78 kcal/mol
Align Score: 170
miRNA  3' ccCUCACUUCUGUG-CCUCGGUCu 5' hsa-miR-149-5p
            ||| ||||| |: |||||||| 
target 5' tgGAG-GAAGAGATGGGAGCCAGa 3' PRMT5-AS1
Start: 505  End: 527
Energy: -34.78 kcal/mol
Align Score: 170
miRNA  3' ccCUCACUUCUGUG-CCUCGGUCu 5' hsa-miR-149-5p
            ||| ||||| |: |||||||| 
target 5' tgGAG-GAAGAGATGGGAGCCAGa 3' PRMT5-AS1
Start: 233  End: 255
Energy: -34.78 kcal/mol
Align Score: 170
miRNA  3' ccCUCACUUCUGUG-CCUCGGUCu 5' hsa-miR-149-5p
            ||| ||||| |: |||||||| 
target 5' tgGAG-GAAGAGATGGGAGCCAGa 3' PRMT5-AS1
Start: 216  End: 238
Energy: -34.78 kcal/mol
Align Score: 170
TargetScan target site prediction
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
                |||||     ||||||| 
target 5'  UGGAGGAAGAGAUGGGAGCCAGA PRMT5-AS1
Start: 723  End: 730
Site type: 8mer-1a
Context++ Score: -0.413
miRNA  3' CCCUCACUUCUGUGC-CUCGGUCU 5' hsa-miR-149-5p
                |||||     ||||||| 
target 5'  UGGAGGAAGAGAUGGGAGCCAGA PRMT5-AS1
Start: 723  End: 730
Site type: 8mer-1a
Context++ Score: -0.413
RNAbybrid target site prediction
miRNA  3' C    A     G              5' hsa-miR-149-5p
           CCUC CUUCU UG CCUCGGUCU    
           GGAG GAAGA AU GGAGCCAGA    
target 5' U          G  G         A 3' PRMT5-AS1
Start: 708  End: 728
Energy: -37.2 kcal/mol
Align Score: 0.001296
miRNA  3' C    A     G              5' hsa-miR-149-5p
           CCUC CUUCU UG CCUCGGUCU    
           GGAG GAAGA AU GGAGCCAGA    
target 5' U          G  G         A 3' PRMT5-AS1
Start: 505  End: 525
Energy: -37.2 kcal/mol
Align Score: 0.001192
miRNA  3' C    A     G              5' hsa-miR-149-5p
           CCUC CUUCU UG CCUCGGUCU    
           GGAG GAAGA AU GGAGCCAGA    
target 5' U          G  G         A 3' PRMT5-AS1
Start: 233  End: 253
Energy: -37.2 kcal/mol
Align Score: 0.001274
miRNA  3' C    A     G              5' hsa-miR-149-5p
           CCUC CUUCU UG CCUCGGUCU    
           GGAG GAAGA AU GGAGCCAGA    
target 5' U          G  G         A 3' PRMT5-AS1
Start: 216  End: 236
Energy: -37.2 kcal/mol
Align Score: 0.00082
miRNA  3' C    A     G              5' hsa-miR-149-5p
           CCUC CUUCU UG CCUCGGUCU    
           GGAG GAAGA AU GGAGCCAGA    
target 5' U          G  G         A 3' PRMT5-AS1
Start: 213  End: 233
Energy: -37.2 kcal/mol
Align Score: 0.00094

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for PRMT5-AS1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-149-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for MTHFR

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 14q11.2

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.