Basic Info

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Basic Information for the CNV-ceRNA event

Cytoband

8q24.21

lncRNA

PVT1 ( ENSG00000249859)

miRNA

hsa-miR-744-5p (MIMAT0004945)

mRNA

TLE3 (ENSG00000140332)

Disease

PAAD

FDR

4.49E-4

Reported as biomarkers
11

Circulating
6

Drug resistent
51

Survival

Binding Info

miRNA Binding site information on lncRNA

miRanda target site prediction
                                           
                       NA                  
                                           
                         
            NA
TargetScan target site prediction
                                           
                       NA                  
                                           
                         
            NA
RNAbybrid target site prediction
miRNA  3 A    AA          GG     5 hsa-miR-744-5p
           CGAC  UCGGGAUCGG  CGU    
           GCUG  GGCCUUGGCU  GUA    
target 5 A    GG               A 3 PVT1
Start: 335  End: 355
Energy: -32.2 kcal/mol
Align Score: 0.006389
miRNA  3 A    AA          GG     5 hsa-miR-744-5p
           CGAC  UCGGGAUCGG  CGU    
           GCUG  GGCCUUGGCU  GUA    
target 5 A    GG               A 3 PVT1
Start: 426  End: 446
Energy: -32.2 kcal/mol
Align Score: 0.003374
miRNA  3 A    AA          GG     5 hsa-miR-744-5p
           CGAC  UCGGGAUCGG  CGU    
           GCUG  GGCCUUGGCU  GUA    
target 5 A    GG               A 3 PVT1
Start: 311  End: 331
Energy: -32.2 kcal/mol
Align Score: 0.002254
miRNA  3 A    AA   GGAU          G   5 hsa-miR-744-5p
           CGAC  UCG        CGGGGC U    
           GCUG  AGC        GCCCCG G    
target 5 A    CG   AAAGAUGU      G A 3 PVT1
Start: 62  End: 82
Energy: -29.8 kcal/mol
Align Score: 0.007
miRNA  3 A    AA          GG     5 hsa-miR-744-5p
           CGAC  UCGGGAUCGG  CGU    
           GCUG  GGCCUUGGCU  GUA    
target 5 A    GG               A 3 PVT1
Start: 329  End: 349
Energy: -32.2 kcal/mol
Align Score: 0.004483

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

Samples with different CNV status

Annotations

External Annotation for PVT1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-744-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for TLE3

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: 8q24.21

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.