Basic Info

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Basic Information for the mutation-ceRNA event

Mutation

chr11:65444515(C/A)

lncRNA

NEAT1 ( ENSG00000245532, ENST00000501122)

miRNA

hsa-miR-328-3p (MIMAT0000752)

mRNA

H2AFX (ENSG00000188486)

Disease

UCEC

FDR

3.83E-4

Reported as biomarkers
7

Circulating
6

Drug resistent
41

Survival

Binding Info

Altered binding affnity between reference and alternative allele

miRanda reference allele   (loss)
                                           
                       NA                  
                                           
                         
            NA
miRanda alternative allele   (loss)
                                           
                       NA                  
                                           
                         
            NA
TargetScan reference allele   (loss)
                                           
                       NA                  
                                           
                         
            NA
TargetScan alternative allele   (loss)
                                           
                       NA                  
                                           
                         
            NA
RNAhybrid reference allele   (gain)
miRNA  3' UG        UCUC      UC 5' hsa-miR-328-3p
            CCUUCCCG    UCCCGG     
            GGAGGGGC    GGGGCC     
target 5'  A        UCCA      C  3' NEAT1
Start: 23  End: 43
Energy: -34.2 kcal/mol
Align Score: 0.000038
RNAhybrid alternative allele   (gain)
miRNA  3' UG       GUCUC      UC 5' hsa-miR-328-3p
            CCUUCCC     UCCCGG     
            GGAGGGG     GGGGCC     
target 5'  A       AUCCA      C  3' NEAT1
Start: 23  End: 43
Energy: -31 kcal/mol
Align Score: 0.000186

Functions

Dysregulated fucntions of CNV-ceRNA event

Hallmarks

Dysregulated hallmarks of CNV-ceRNA event

Network

Related ceRNA network disturbed by CNV

Survival

Survival status of ceRNA interaction

Samples

The somatic mutation chr11:65444515 identified in the following paired samples.

TCGA-AP-A0LM-01A-11D-A122-09

TCGA-AP-A0LM-10A-01D-A122-09

Annotations

External Annotation for NEAT1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-328-3p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for H2AFX

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: chr11:65444515

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.