Basic Info

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Basic Information for the SNP-ceRNA event

Variation

rs362052  chr22:18125635(T/C)

lncRNA

AC008079.1 ( ENSG00000280007)

miRNA

hsa-miR-149-5p (MIMAT0000450)

mRNA

BBC3 (ENSG00000105327)

Population

EUR_YRI

FDR

2.07E-6

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

Altered binding affnity between reference and alternative allele

miRanda reference allele   (gain)
miRNA  3' cccUCACUUC-UGUGCCUCGGUCu 5' hsa-miR-149-5p
             ||  |:| |||:|||||||| 
target 5' uucAGAAAGGUACAUGGAGCCAGa 3' AC008079.1
Start: 44  End: 67
Energy: -28.38 kcal/mol
Align Score: 167
miRanda alternative allele   (gain)
miRNA  3' cccucaCUUCUGUGCCUCGGUCu 5' hsa-miR-149-5p
                |:: |||:|||||||| 
target 5' ucagaaGGGUACAUGGAGCCAGa 3' AC008079.1
Start: 45  End: 67
Energy: -29.6 kcal/mol
Align Score: 165
TargetScan reference allele   (gain)
miRNA  3' CCCUCACUUCUGUGC--CUCGGUCU 5' hsa-miR-149-5p
                 |||       ||||||| 
target 5'   UCAGAAAGGUACAUGGAGCCAGA AC008079.1
Start: 60  End: 67
Site type: 8mer-1a
Context++ Score: -0.446
TargetScan alternative allele   (gain)
miRNA  3' CCCUCACUUCUGUGC---CUCGGUCU 5' hsa-miR-149-5p
                ||||        ||||||| 
target 5'    UCAGAAGGGUACAUGGAGCCAGA AC008079.1
Start: 60  End: 67
Site type: 8mer-1a
Context++ Score: -0.44
RNAhybrid reference allele   (gain)
miRNA  3'                 AC                   5' hsa-miR-149-5p
           CCC          UC  UUC UGUGCCUCGGUCU    
           GGG          AG  AGG ACAUGGAGCCAGA    
target 5' A   CACCAAUUUC  AA   U             A 3' AC008079.1
Start: 33  End: 53
Energy: -32.5 kcal/mol
Align Score: 0.000277
RNAhybrid alternative allele   (gain)
miRNA  3' CCCUCA                      5' hsa-miR-149-5p
                CUUC   UGUGCCUCGGUCU    
                GAAG   ACAUGGAGCCAGA    
target 5'      A    GGU             A 3' AC008079.1
Start: 47  End: 67
Energy: -33.1 kcal/mol
Align Score: 0.00021

Functions

Dysregulated fucntions of SNP-ceRNA event

Hallmarks

Dysregulated hallmarks of SNP-ceRNA event

Network

The AC008079.1-associated ceRNA network which were dysregulated by rs362052

Related ceRNA network disturbed by SNP

Survival

Survival status of ceRNA interaction

Samples

Samples with different genotypes

Annotations

External Annotation for AC008079.1

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-149-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for BBC3

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: rs362052

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.