Basic Info

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Basic Information for the SNP-ceRNA event

Variation

rs7284593  chr22:31053775(G/A)

lncRNA

AC005005.4 ( ENSG00000278920)

miRNA

hsa-miR-34a-5p (MIMAT0000255)

mRNA

MCM5 (ENSG00000100297)

Population

FIN

FDR

3.65E-4

Reported as biomarkers
0

Circulating
0

Drug resistent
0

Survival

Binding Info

Altered binding affnity between reference and alternative allele

miRanda reference allele   (gain)
miRNA  3' uguUGGUCGAUUC--UGUGACGGu 5' hsa-miR-34a-5p
             :||| ||::|  |||||||| 
target 5' uucGCCAACUGGGACACACUGCCa 3' AC005005.4
Start: 41  End: 64
Energy: -25.69 kcal/mol
Align Score: 162
miRanda alternative allele   (gain)
miRNA  3' uguUGGUCGAUUC--UGUGACGGu 5' hsa-miR-34a-5p
             :||| |||:|  |||||||| 
target 5' uucGCCAACUAGGACACACUGCCa 3' AC005005.4
Start: 41  End: 64
Energy: -26.17 kcal/mol
Align Score: 166
TargetScan reference allele   (gain)
miRNA  3'   UGUUGGUCGAUUCUGUGACGGU 5' hsa-miR-34a-5p
                          ||||||| 
target 5'  UCGCCAACUGGGACACACUGCCA AC005005.4
Start: 57  End: 64
Site type: 8mer-1a
Context++ Score: -0.404
TargetScan alternative allele   (gain)
miRNA  3'   UGUUGGUCGAUUCUGUGACGGU 5' hsa-miR-34a-5p
                          ||||||| 
target 5'  UCGCCAACUAGGACACACUGCCA AC005005.4
Start: 57  End: 64
Site type: 8mer-1a
Context++ Score: -0.425
RNAhybrid reference allele   (gain)
miRNA  3'             C                  5' hsa-miR-34a-5p
           UGU    UGGU GAUUCUGUG  ACGGU    
           ACA    GCCA CUGGGACAC  UGCCA    
target 5' C   GUUC    A         AC     C 3' AC005005.4
Start: 36  End: 56
Energy: -31 kcal/mol
Align Score: 0.00051
RNAhybrid alternative allele   (gain)
miRNA  3'             C                  5' hsa-miR-34a-5p
           UGU    UGGU GAUUCUGUG  ACGGU    
           ACA    GCCA CUAGGACAC  UGCCA    
target 5' C   GUUC    A         AC     C 3' AC005005.4
Start: 36  End: 56
Energy: -31.4 kcal/mol
Align Score: 0.000424

Functions

Dysregulated fucntions of SNP-ceRNA event

Hallmarks

Dysregulated hallmarks of SNP-ceRNA event

Network

The AC005005.4-associated ceRNA network which were dysregulated by rs7284593

Related ceRNA network disturbed by SNP

Survival

Survival status of ceRNA interaction

Samples

Samples with different genotypes

Annotations

External Annotation for AC005005.4

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.



External Annotation for hsa-miR-34a-5p

A high quality database of published miRNA sequences and annotation.

A curated miRNA-target database developed by DIANA LAB.

A miRNA-target database by manually filter research articles related to functional studies of miRNAs.

A comprehensive of microRNA diversity, expression profiles, target relationships, and various supporting tools.



External Annotation for MCM5

Information on all annotated and predicted human genes.

Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information).

Genome browser for vertebrate genomes.

An annotated collection of all publicly available DNA sequences.



External Annotation for variation: rs7284593

A comprehensive, authoritative compendium of human genes and genetic phenotypes.

A database of human single nucleotide variations, microsatellites, and small-scale insertions and deletions

The catalogue of somatic mutations in cancer.