Basic Info
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Basic Information for the variation-ceRNA event
rs2366152 12:53962605(A/G)
HOTAIR ( ENSG00000228630)
hsa-miR-22 (MIMAT0004495)
NA ()
cervical cancer tissues
cervical cancer
Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis.
This genetic variant showed the propensity of a secondary structure alteration and gain of a miR-22 binding site in HOTAIR, which was found to be concordant with miR-22 over-expression in low HOTAIR CaCx cases compared to controls. We found that miR-22 expression negatively correlated with HOTAIR and E7 expression in HPV16 positive cases and in an E7 transfected HPV negative CaCx-derived cell line (C33A), but was not altered in high HOTAIR cases compared to controls. Reduced luciferase activity of a HOTAIR rs2366152C expression plasmid in C33A cells through miR-22 co-transfection confirmed the ability of miR-22 to specifically target rs2366152C-harbouring HOTAIR lncRNA in CaCx cells, ultimately leading to its down-regulation.
 Circulating |
 Drug resistent |
 Survival |
Annotations
External Annotation for HOTAIR
LncRNA-associated competing triplets and functions.
Comprehensive experimentally supported associations between lncRNA and human cancer.
An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.
An integrated knowledge database dedicated to non-coding RNAs.
An integrated database of human annotated lncRNA transcripts.
Comprehensive annotations of eukaryotic long non-coding RNAs.