Basic Info

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Basic Information for the variation-ceRNA event

Variation

rs4759314  12:53968051(A/G)

lncRNA

HOTAIR ( ENSG00000228630)

miRNA

hsa-miR-331-3p (MIMAT0000760)

mRNA

HOXC11 (ENSG00000123388)

Tissues

Gastric cancer tissue

Disease

gastric cancer

Pubmed Id
Title

The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population

Description

Functional experiments revealed the allele-specific effects on HOTAIR and HOXC11 expressions in gastric cancer tissues, of which HOTAIR and HOXC11 expressions of individuals carrying with AG genotype were much higher than those with AA genotype; similarly, the effects occurred in intronic promoter activities, of which the promoter activity of G allele was more pronounced than that of A allele.

Reported as biomarkers
43

Circulating

24

Drug resistent

100

Survival

Annotations

External Annotation for HOTAIR

LncRNA-associated competing triplets and functions.

Comprehensive experimentally supported associations between lncRNA and human cancer.

An open-source platform for studying the RNA-RNA interactions from CLIP-seq data.

An integrated knowledge database dedicated to non-coding RNAs.

An integrated database of human annotated lncRNA transcripts.

Comprehensive annotations of eukaryotic long non-coding RNAs.