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e.g. lncRNA "HOTAIR", "ENSG00000228630" , miRNA "hsa-let-7a-5p" , gene "TP53" , disease "BRCA, primary site "Ovary."

Welcome to LncACTdb2.0

LncACTdb 2.0 is an updated database aims to integrate manually curated and predicted ceRNA interactions. The class of ceRNAs in LncACTdb 2.0 contains endogenously generated molecules (including lncRNAs, circular RNAs, coding genes, pseudogenes) and exogenously introduced molecules (including viral RNAs and artifically engineered RNAs). The scope of this database was expanded to more than 20 types of species and hundreds of diseases. LncACTdb 2.0 attempts to provide a comprehensive resource and web tool for clarifying the ceRNA relationships between different types of RNAs in diverse diseases.

Service Provided

New features

1. High-confidence experimentally verified ceRNA interactions were manually curated into LncACTdb 2.0.

2. High-throughput sequencing dataset were used to identify functional ceRNAs across 33 cancer types.

3. Types of ceRNAs were expanded to circular RNAs, coding genes, pseudogenes, viral RNAs, etc.

4. Hundreds of diseases information were integrated into LncACTdb 2.0.

5. More flexible online interfaces (Quick search, BLAST, Hotpoints) have been developed to retrieve the data.

6. The LncACT-Function tool performes functional analysis basd on different GO terms and pathways.

7. The LncACT-Survival tool performs survival analysis for ceRNAs across thousands of patients.

8. The LncACT-Network tool provides graphic illustration of the ceRNA network as customerized input.

9. Detail information of miRNA-target sites (such as seed matching, free energy, etc) was provided.

10. Essential cancer Hallmarks were used to infer lncRNA functions in LncACTdb 2.0.


Resource Links

Please cite:
1. LncACTdb 2.0: an updated database of experimentally supported ceRNA interactions curated from low- and high-throughput experiments, (Nucleic Acids Research, 2018).
2. Identification of lncRNA-associated competing triplets reveals global patterns and prognostic markers for cancer, (Nucleic Acids Research, 2015).
Contact us: Li Xia (lixia@hrbmu.edu.cn)

"Hot points" of LncACTdb2.0

LncACTdb2.0 Statistics

Created with Highcharts 5.0.7 numbers of entries Statistics of curated regulatory relationship between human lncRNAs and DNA methylation Statistics of curated regulatory relationship between human lncRNAs and DNA methylation Aberrantly Trans- methylation Regulated LncRNAs Aberrantly Trans-methylation Regulated LncRNAs Aberrantly Trans- methylation Due to LncRNAs Aberrantly Trans-methylation Due to LncRNAs Aberrantly Cis-methylated LncRNAs Aberrantly Cis-methylated LncRNAs Genetic Diseases Reproduction & Infant Diseases Metabolism Diseases Liver Cancer Breast Cancer Colorectal Cancer Ovarian Cancer Prostate Cancer Leukemia Lung Cancer Wilms' Tumor Gastric Cancer Other Diseases Reproduction & Infant Development Blood & Other Tissues 0 20 40 60 80 Ovarian Cancer Aberrantly Cis-methylated LncRNAs: 14
Created with Highcharts 5.0.7 numbers of transcripts in diseases Identified differentially methylated transcripts in diseases protein-coding pseudogene processed transcript lincRNA Cognitive Disorder Gastrointestinal System Cancer Respiratory System Cancer Urinary System Cancer Reproductive Organ Cancer Thoracic Cancer Immune System Cancer Malignant Glioma Monogenic Disease Endocrine Gland Cancer Nervous System Cancer Head and Neck Cancer Chromosomal Disease Small bowel adenocarcinoma Viral Infectious Disease Gastrointestinal System Disease Other Diseases 0 50k 100k 150k 200k

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