Basic Information
| LncRNA/CircRNA Name | LINC001152 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | HCC tissues and corresponding normal tissues ,cell lines(Huh7, HepG2 and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | The expression of LINC01152 was significantly increased in HBV positive HCC tissues and cells and was induced by HBx in vitro.The overexpression of LINC01152 could increases HCC cell proliferation and promotes tumor formation in nude mice.Mechanistically, HBx could increase the transcription of LINC01152.Elevated LINC01152 binds to the promoter region of IL-23, promoting its transcriptional activity and upregulating the levels of Stat3 and p-Stat3. |
| Pubmed ID | 31054511 |
| Year | 2019 |
| Title | HBx-related Long Non-Coding RNA 01152 Promotes Cell Proliferation and Survival by IL-23 in Hepatocellular Carcinoma |
External Links
| Links for LINC001152 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |