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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular cancer
ICD-0-3	NA
Methods	qRT-PCR, Northern blots Assays, Western blots Assays, circRIP, Luciferase Reporter Assay, Cell growth assay, Flow cytometric analysis, Cell invasion and migration assay, Xenograft models of Hepatocellular carcinoma in mice
Sample	HCC tissues, HCC cell lines (HepG2, SMMC-7721, HuH-6 and SK-Hep1) and the nonmalignant LO2 hepatocytes
Expression Pattern	up-regulated
Function Description	Expression levels of has_circ_0078710 were tested in both HCC tissue samples and cells using real-time qRT-PCR. Has_circ_0078710 was significantly unregulated in HCC tissues and cells. Moreover, HCC patients with high level of has_circ_0078710had the advance stage (TNM III-IV).Finally, we constructed an interaction network among circRNA-miRNA-mRNA and we identified miR-31 as thehas_circ_0078710-associatedmiRNA. Furthermore, overexpression of has_circ_0078710 in HCC could up-regulate HDAC and CDK2 levels by sponging miR-31, simultaneously mediating the expression of cell cycle components (cyclin A, cyclin D1, CDK4) and negative cell cycle regulator p21. In vitro and in vivo functional studies showed that overexpression of has_circ_0078710in HepG2, SMMC-7721 cell lines significantly promoted cell proliferation, migration, invasion and tumor growth by inducing the cell cycle progression.
Pubmed ID	30342168
Year	2018
Title	CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression

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