Basic Information
| LncRNA/CircRNA Name | circADAMTS14 |
| Synonyms | circ_0018665 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular cancer |
| ICD-0-3 | NA |
| Methods | qRT??CR, CCK?? assay, Wound??ealing assay, Apoptosis analysis, Transwell assay, Luciferase reporter assay, Western blot |
| Sample | HCC tissues, HCC cell lines HepG2, SK??EP??, SMMC??721, and QGY??703, and normal hepatic cell line QSG??701 |
| Expression Pattern | down-regulated |
| Function Description | CircADAMTS14 and RCAN1 were lowly expressed in HCC clinical specimens and cell lines using microarrays and qRT PCR, but miR-572 inversely. Our study further verified the direct interaction between circADAMTS14 and RCAN1 with miR-572 via the dual luciferase reporter gene assay. Overexpressed circADAMTS14 and RCAN1 induced apoptosis of HCC cells and inhibited cell proliferation and invasion. But overexpressed miR-572 could decrease apoptosis of HCC cells and promote proliferation and invasion. In vivo, circADAMTS14 inhibited the tumor growth, correlated positively with the protein expression levels of RCAN1. Our results demonstrated that circADAMTS14 might suppress HCC progression through regulating miR-572/RCAN1 as the competing endogenous RNA. |
| Pubmed ID | 30317540 |
| Year | 2018 |
| Title | The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1 |
External Links
| Links for circADAMTS14 | GenBank HGNC NONCODE |
| Links for hepatocellular cancer | OMIM COSMIC |