Basic Information
| LncRNA/CircRNA Name | circ_001569 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RNA pull-down, RT-PCR, Western blot, Luciferase reporter assay, CCK8, Annexin V/PI staining, Cell cycle, Nude mice xenografts |
| Sample | gastric cancer tissues, gastric cancer cell lines SGC-7901 and MGC-803, human normal gastric mucosal cell line GES-1 |
| Expression Pattern | up-regulated |
| Function Description | Both circRNA_001569 and NR4A2 were overexpressed in tissues and cells of gastric cancer, while miR-145 was down-regulated. Overexpressed circRNA_001569 significantly increased cell viability, and decreased cell apoptosis, while down-regulated circRNA_001569 dramatically decreased cell viability and promoted cell apoptosis. CircRNA_001569 regulated the expression of miR-145, the effect of pcDNA-circRNA_001569 was abolished by miR-145 mimic, and the effect of si-circRNA_001569 was abolished by miR-145 inhibitor. MiR-145 targets NR4A2 to regulate its expression. Overexpressed miR-145 suppressed cell viability and promoted cell apoptosis. |
| Pubmed ID | 30304349 |
| Year | 2018 |
| Title | CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer |
External Links
| Links for circ_001569 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |