Basic Information
| LncRNA/CircRNA Name | circZNF609 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Animal studies, IHC, Cell viability assay, EdU incorporation assay, Transwell migration and invasion assays, Wound healing assay, Dual Luciferase reporter assay, Western blotting |
| Sample | breast cancer tissues, cell lines MCF-10A, MCF-7, T47D, MDA-MB-231, BT-549 |
| Expression Pattern | up-regulated |
| Function Description | CircZNF609 was markedly over-expressed in breast cancer tissues and cell lines, and high circZNF609 expression was closely associated with poor outcome. Silencing of circZNF609 inhibited the malignant phenotype of breast cancer in vitro and in vivo. Mechanistically, circZNF609 served as a sponge of miR-145-5p to elevate p70S6K1 expression. Moreover, miR145-5p overexpression or p70S6K1 knockdown abrogated the oncogenic effects of circZNF609 in breast cancer. In addition, clinically, a strong negative correlation was observed between the expression of circZNF609 and miR-145-5p in breast cancer tissues (r= 0.597, P<0.001), whereas a positive correlation between circZNF609 and p70S6K1 expression (r=0.319, P<0.001). |
| Pubmed ID | 30288120 |
| Year | 2018 |
| Title | CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p |
External Links
| Links for circZNF609 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |