Basic Information
| LncRNA/CircRNA Name | circ-102004 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-PCR, Cell Proliferation Assay, Scratch Test (Cell Migration Assay), Transwell Assay (Cell Invasion Assay), Flow Cytometry for the Apoptosis and Cycle Analysis, Western blotting Assay, Establishment of Tumor Xenograft Mice Model |
| Sample | PCa tissues, PCa cell lines PC3 and 22RV1 |
| Expression Pattern | up-regulated |
| Function Description | circ-102004 expression was found to be significantly higher in PCa samples than in the matched normal tissues. In functional experiments, circ-102004 is shown to play an oncogenic role in PCa by stimulating cancer cell migration and invasion. Circ-102004 overexpression was also accompanied by significant alterations in many signaling pathways, such as ERK, JNK, and Hedgehog, which are known to cause different types of cancers. |
| Pubmed ID | 30219508 |
| Year | 2018 |
| Title | Upregulated Circular RNA Circ-102004 That Promotes Cell Proliferation in Prostate Cancer |
External Links
| Links for circ-102004 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |