Basic Information
| LncRNA/CircRNA Name | circ_100290 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Cell proliferation assay, Western blot, Transwell assays, Cell apoptosis assays, qRT-PCR, Dual luciferase activity assay |
| Sample | CRC tissues, CRC cell lines (HCT116, SW480, HT29 and SW620) and normal colon epithelial cell line (NCM460) |
| Expression Pattern | up-regulated |
| Function Description | circRNA_100290 level was significantly increased in CRC tissues and cell lines. Besides, circRNA_100290 expression was positively correlated with tumor metastasis while inversely correlated with prognosis. Silencing circRNA_100290 markedly reduced cell proliferation rate, inhibited migration and invasion abilities, but promoted apoptosis in vitro. Mechanistically, our data revealed circRNA_100290 was a competing endogenous RNA (ceRNA) of FZD4 by sponging miR-516b, leading to activation of Wnt/b-catenin pathway. Rescue assay indicated that FZD4-induced activation of b-catenin pathway is indispensable for the function of circRNA_100290 in CRC. |
| Pubmed ID | 30173892 |
| Year | 2018 |
| Title | CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/bcatenin signaling |
External Links
| Links for circ_100290 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |