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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	breast cancer
ICD-0-3	C50
Methods	qRT-PCR, Cell viability analysis, Cell proliferation analysis, Cell invasion analysis, Apoptosis and cell cycle analysis, Dual luciferase activity assay, circRNA immunoprecipitation, Western blot, Hematoxylin and eosin (HE) staining, Immunohistochemical analysis
Sample	BC tissues, BC cell lines (MCF-1, MDA-MB-231, MDA-MB-468, SKBR-3, and MDA-MB-453) and normal human mammary epithelial cell line (MCF-10A)
Expression Pattern	up-regulated
Function Description	the significantly upregulated expression of hsa_circ_0007534 circRNA in BC tissues and cell lines. In contrast, miR593 expression was significantly downregulated. Knockdown of hsa_circ_0007534 inhibited BC cell proliferation, colony formation, and invasion, and promoted apoptosis in BC cells. Moreover, hsa_- circ_0007534 was demonstrated to be a sponge of miR-593, and expression of miR-593 in BC cells was negatively correlated with hsa_circ_0007534. MUC19 expression was markedly increased in BC tissues and cell lines, and the 3 -UTR of MUC19 was targeted by miR-593. The expression of MUC19 was negatively regulated by miR-593 in BC cells. Our findings suggest an oncogenic role for hsa_circ_0007534 in BC by acting as a miR-593 sponge to promote MUC19 expression.
Pubmed ID	30139516
Year	2018
Title	Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway

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