Basic Information
| LncRNA/CircRNA Name | circ_0056618 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Colony formation assay, CCK??, Dual??uciferase reporter assay, qRT??CR, Western blot |
| Sample | gastric cancer malignant tissues, gastric cancer (MKN??5, MGC??03, NCI??87, SNU??, KATO III, HGC??7, BGC??23, SGC??901, AGS) and normal human gastric epithelial cells (GES??) |
| Expression Pattern | up-regulated |
| Function Description | The real time polymerase chain reaction result showed that circ_0056618 was overexpressed in tumor tissues or cells compared with adjacent normal tissues or normal cells and had a negative relationship to gastric cancer patients survival time. Meanwhile, the inhibition of circ_0056618 suppressed the proliferation and metastasis of gastric cancer cells. Further bioinformatical analysis indicated that circ_0056618 sponged miR 206 to regulate CXCR4 according to the prediction of TargetScan and miRanda. Dual luciferase reporter assay and Western blot analysis revealed the underlying relationship of circ_0056618, miR 206, and CXCR4. Hence, circ_0056618 negatively regulated miR 206 expression promoting CXCR4 expression. |
| Pubmed ID | 30129184 |
| Year | 2018 |
| Title | Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR??06 |
External Links
| Links for circ_0056618 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |