Basic Information
| LncRNA/CircRNA Name | circCEP128 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Bladder Cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, western blot, luciferase reporter assay, RNAi, other |
| Sample | bladder cancer tissues and cells lines (RT-112, 5637, BIU-87 and TCCSUP) |
| Expression Pattern | up-regulated |
| Function Description | In present study, circCEP128 and SOX11 were observed significantly up-regulated in bladder cancer tissues, while the expression of miR-145-5p was decreased in cancer samples compared to normal samples. Cytoscape was used to visualize circCEP128-miRNA-target gene interactions based on the TargetScan and circular RNA interactome, which revealed that circCEP128 served as a sponge of miR-145-5p and indirectly regulated SOX11. Knockdown of circCEP128 induced the inhibition of cell proliferation and the increased bladder cancer cell apoptosis rate. |
| Pubmed ID | 30134837 |
| Year | 2018 |
| Title | Circular RNA CEP128 Acts as a Sponge of miR-145-5p in Promoting the Bladder Cancer Progression via Regulating SOX11 |
External Links
| Links for circCEP128 | GenBank HGNC NONCODE |
| Links for Bladder Cancer | OMIM COSMIC |