Basic Information
| LncRNA/CircRNA Name | circ_0066444 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, other |
| Sample | GC tissues and cell lines (MKN-45, BGC-823, MGC-803) |
| Expression Pattern | up-regulated |
| Function Description | circ_0066444 was found to be significantly upregulated in 106 GC tissues as compared with paired adjacent nontumorous tissues (P=0.025), showing a high positive correlation with lymphatic metastasis (P=0.023). Furthermore, in vitro assays of the GC cell lines BGC-823 and AGS demonstrated that knockdown of circ_0066444 reduced cell proliferation, invasion, and migration significantly. Prediction and annotation revealed circ_0066444 was able to sponge to 5 miRNAs and 15 corresponding target mRNAs. |
| Pubmed ID | 29785124 |
| Year | 2018 |
| Title | Upregulation of circ_0066444 Promotes the Proliferation, Invasion, and Migration of Gastric Cancer Cells |
External Links
| Links for circ_0066444 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |