Basic Information
| LncRNA/CircRNA Name | circ_0067934 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, western blot, other |
| Sample | NSCLC tissues and cell lines (A549, H1299, H358, SPCA1) |
| Expression Pattern | up-regulated |
| Function Description | High circ_0067934 expression was significantly associated with TNM stage (p=0.003), lymph node status (p=0.000), and distant metastasis (p=0.017). Moreover, Kaplan-Meier curves showed that higher expression of circ_0067934 led to a significantly poorer survival. Multivariate Cox proportional hazards analysis suggested that circ_0067934 was an independent poor prognostic factor for patients with NSCLC. In vitro assay indicated that down-regulation of circ_0067934 could suppress NSCLC cells proliferation, migration, and invasion. Mechanistic analysis showed that aberrant circ_0067934 expression could modulate the expression levels of markers of epithelial-to-mesenchymal transition. |
| Pubmed ID | 29863250 |
| Year | 2018 |
| Title | CircRNA circ_0067934 Silencing Inhibits the Proliferation, Migration and Invasion of NSCLC Cells and Correlates With Unfavorable Prognosis in NSCLC |
External Links
| Links for circ_0067934 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |