Basic Information
| LncRNA/CircRNA Name | circCBFB |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, other |
| Sample | CLL cell line MEC-1 cells, HEK293T, blood |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, we found that circ-CBFB could serve as a diagnostic and prognostic biomarker for CLL patients. We also explored the physiological function of circ-CBFB. We found that circ-CBFB knockdown significantly suppressed CLL cell proliferation, arrested cell cycle progression, and induced cellular apoptosis. In terms of its mechanism, we identified circ-CBFB as a sponge of miR-607, which targeted FZD3. By inhibiting miR-607 availability, circ-CBFB promoted FZD3 expression, leading to the activation of the Wnt/?-catenin pathway and consequent CLL progression. |
| Pubmed ID | 29902450 |
| Year | 2018 |
| Title | Circular RNA circ-CBFB Promotes Proliferation and Inhibits Apoptosis in Chronic Lymphocytic Leukemia Through Regulating miR-607/FZD3/Wnt/?-catenin Pathway |
External Links
| Links for circCBFB | GenBank HGNC NONCODE |
| Links for chronic lymphocytic leukemia | OMIM COSMIC |