Basic Information
| LncRNA/CircRNA Name | circFARSA |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNA-seq, other |
| Sample | lung cancer tissues cell line (A549), plasma |
| Expression Pattern | up-regulated |
| Function Description | A circRNA derived from exon 5-7 of the FARSA gene, termed circFARSA, was observed to increase in cancerous tissues (P = 0.016), and was more abundant in patients' plasma than controls (P < 0.001). Overexpression of circFARSA in A549 cell line significantly promoted cell migration and invasion. In silico analysis suggested that circFARSA might sponge miR-330-5p and miR-326, thereby relieving their inhibitory effects on oncogene fatty acid synthase. Summarily, this study revealed circRNA profile of NSCLC for the first time and provided the evidence of plasma circFARSA as a potential noninvasive biomarker for this malignancy. |
| Pubmed ID | 29722168 |
| Year | 2018 |
| Title | A Novel Plasma Circular RNA circFARSA Is a Potential Biomarker for Non-Small Cell Lung Cancer |
External Links
| Links for circFARSA | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |