Basic Information
| LncRNA/CircRNA Name | circHIPK3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | Glioma tissues and cell lines (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | Elevated level of circHIPK3 was linked to poor prognosis. Functional investigation indicated that circHIPK3 promotes glioma cell proliferation and invasion, and tumor propagation in vivo. Furthermore, miR-654 was identified as a target of circHIPK3 while IGF2BP3 was targeted by miR-654. CircHIPK3 could promote IGF2BP3 expression via interacting with miR-654 in glioma cells. Finally, CCK8 and transwell assays illustrated that IGF2BP3 overexpression could reverse the effects of IGF2BP3 depletion. |
| Pubmed ID | 30057315 |
| Year | 2018 |
| Title | CircRNA circHIPK3 Serves as a Prognostic Marker to Promote Glioma Progression by Regulating miR-654/IGF2BP3 Signaling |
External Links
| Links for circHIPK3 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |