Basic Information
| LncRNA/CircRNA Name | circITCH |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | PTC tissues and cell lines (K1, IHH4, and TPC1) |
| Expression Pattern | up-regulated |
| Function Description | Gain-of-functional assays show that circ-ITCH overexpression suppresses PTC cell proliferation and invasion and promotes apoptosis in vitro. Overexpression of circ-ITCH also leads to impaired tumor growth in vivo. Bioinformatics analysis and luciferase reporter assays demonstrate that circ-ITCH sponges miR-22-3p to upregulate the expression of CBL, an E3 ligase of nuclear ?-catenin. Elevated levels of CBL suppress activation of the Wnt/?-catenin pathway and consequently attenuates PTC progression. |
| Pubmed ID | 30190130 |
| Year | 2018 |
| Title | CircRNA circ-ITCH Suppresses Papillary Thyroid Cancer Progression Through miR-22-3p/CBL/?-catenin Pathway |
External Links
| Links for circITCH | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |