Detail

Basic Information

LncRNA/CircRNA Name	circITCH
Synonyms
Region
Ensemble
Refseq

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	Bladder Cancer
ICD-0-3	C67
Methods	qPCR, western blot, luciferase reporter assay, other
Sample	BCa tissues and cell lines
Expression Pattern	down-regulated
Function Description	In the present study, we found that circ-ITCH, is down-regulated in BCa tissues and cell lines. BCa patients with low circ-ITCH expression had shortened survival. Enforced- expression of circ-ITCH inhibited cells proliferation, migration, invasion and metastasis both in vitro and in vivo. Mechanistically, we demonstrated that circ-ITCH up-regulates the expression of miR-17 and miR-224 target gene p21 and PTEN through 'sponging' miR-17 and miR-224, which suppressed the aggressive biological behaviors of BCa.
Pubmed ID	29386015
Year	2018
Title	Circular RNA circ-ITCH Inhibits Bladder Cancer Progression by Sponging miR-17/miR-224 and Regulating p21, PTEN Expression

External Links

Links for circITCH	GenBank HGNC NONCODE
Links for Bladder Cancer	OMIM COSMIC