Basic Information
| LncRNA/CircRNA Name | circMAN2B2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | lung cancer tissues and cell lines (A549, H226, H1299 and H446) |
| Expression Pattern | up-regulated |
| Function Description | Mechanistically, we found that circMAN2B2 could sponge miR-1275 to inhibit its level. Through a series of functional experiments, we dissected the role of miR-1275 in lung cancer and proved the anti-tumor role of miR-1275. Furthermore, we found that miR-1275 exerted its role in lung cancer by regulating FOXK1 expression. In addition, we demonstrated that restoration of FOXK1 could rescue circMAN2B2 knockdown-induced repression of cell proliferation and invasion. Taken together, our study demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275. |
| Pubmed ID | 29550475 |
| Year | 2018 |
| Title | Circular RNA circMAN2B2 Facilitates Lung Cancer Cell Proliferation and Invasion via miR-1275/FOXK1 Axis |
External Links
| Links for circMAN2B2 | GenBank HGNC NONCODE |
| Links for Lung Cancer | OMIM COSMIC |