Basic Information
| LncRNA/CircRNA Name | circNT5E |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, Microarray, RNAi, other |
| Sample | Glioblastoma tissues and cell lines (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | We characterized a novel circRNA derived from NT5E, named circNT5E, that is regulated by ADARB2 binding to sites flanking circRNA-forming introns. We hypothesized that circNT5E may serve as a sponge against miR-422a in glioblastoma tumorigenesis. circNT5E controlled multiple pathologic processes, including cell proliferation, migration, and invasion. circNT5E directly bound miR-422a and inhibited miR-422a activity. Furthermore, circNT5E was observed to sponge other miRNAs, exhibiting tumor suppressor-like features in glioblastoma. Taken together, these findings highlight a novel oncogenic function of circRNA in glioblastoma tumorigenesis |
| Pubmed ID | 29967262 |
| Year | 2018 |
| Title | CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis |
External Links
| Links for circNT5E | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |