Basic Information
| LncRNA/CircRNA Name | circPAX2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Lung Cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, luciferase reporter assay, Microarray, other |
| Sample | lung cancer tissues and cell lines (NCIH2170, SPC-A-1, H460 and A549) |
| Expression Pattern | up-regulated |
| Function Description | Functional validation experiments showed that knockdown of circ-PAX2 promoted apoptosis of lung carcinoma cells, and then suppressed proliferation and migration of tumor cells. Small interfering RNA (siRNA) to circ-PAX2 inhibited growth in lung tumor cells. Bioinformatics prediction and rescue experiments showed that circ-PAX2 was a target of microRNA-186, confirmed by qRT-PCR and double luciferase reporter assay. On the whole, our findings reveal that circ-PAX2 was up-regulated and may be an oncogene in lung cancer; its function was reducing apoptosis, promoting cell proliferation and migration in lung carcinoma cells, which might be a novel therapeutic targetgene in lung cancer. |
| Pubmed ID | 31949766 |
| Year | 2018 |
| Title | Circ-PAX2 Promotes Proliferation and Metastasis by Absorbing miR-186 in Lung Cancer Cells |
External Links
| Links for circPAX2 | GenBank HGNC NONCODE |
| Links for Lung Cancer | OMIM COSMIC |