Basic Information
| LncRNA/CircRNA Name | circRBMS3 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Gastric Cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, luciferase reporter assay, other |
| Sample | GC tissues and cell lines (SGC??901, MKN??8, MKN??5, HGC??7, BGC??23, and AGS) |
| Expression Pattern | up-regulated |
| Function Description | Correlation analysis revealed that high circRBMS3 expression was associated with advanced TNM stage, depth of invasion, and lymph-node metastasis. Kaplan-Meier analysis indicated that GC patients with high circRBMS3 expression have a poor overall survival (OS). Function assays showed that circRBMS3 silencing reduced GC cells proliferation and invasion in vitro, and inhibited the tumor growth in vivo. Mechanistically, we found that miR-153 could act as a target of circRBMS3. Subsequently, we showed that circRBMS3 promoted snail family zinc finger 1 (SNAI1) expression via inhibiting miR-153 in GC cells. |
| Pubmed ID | 30132886 |
| Year | 2019 |
| Title | CircRBMS3 Promotes Gastric Cancer Tumorigenesis by Regulating miR-153-SNAI1 Axis |
External Links
| Links for circRBMS3 | GenBank HGNC NONCODE |
| Links for Gastric Cancer | OMIM COSMIC |