Basic Information
| LncRNA/CircRNA Name | circ_0023642 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Gastric Cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, western blot, other |
| Sample | GC tissues and cell lines (MGC-803, MNK-45,SGC-7901 and HGC-27) |
| Expression Pattern | up-regulated |
| Function Description | We found that circRNA_0023642 was upregulated in GC tissues and cell lines. Functionally, down-regulation of circRNA_0023642 displayed the tumor-inhibitory effects by suppressing cell proliferation, migration, and invasion as well as inducing apoptosis. Mechanically, our results revealed that the abnormal expression of circRNA_0023642 could influence the EMT signaling pathway, which was demonstrated by measuring the expression levels of N-cadherin, vimentin snail, and E-cadherin. |
| Pubmed ID | 29762831 |
| Year | 2018 |
| Title | CircRNA_0023642 Promotes Migration and Invasion of Gastric Cancer Cells by Regulating EMT |
External Links
| Links for circ_0023642 | GenBank HGNC NONCODE |
| Links for Gastric Cancer | OMIM COSMIC |