Basic Information
| LncRNA/CircRNA Name | circ_000284 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, western blot, luciferase reporter assay, RIP, other |
| Sample | cervical cancer cell lines ??eLa, CaSki, SiHa, C-33A, SW756? |
| Expression Pattern | up-regulated |
| Function Description | Subsequent mechanistic investigations suggested that knockdown of circRNA-000284 suppressed cell proliferation and invasion, and caused G0/G1 phase cell cycle arrest. By performing anti-AGO2 RNA precipitation and luciferase reporter assay, we identified miR-506 as the circRNA-000284-associated miRNA. Furthermore, Snail-2 was identified as a direct target of miR-506, and circRNA-000284 could positively regulate the expression of Snail-2. Finally, the tumor promoting effect of circRNA-000284 was abolished by co-expression of miR-506 mimics or Snail-2 silencing vector. |
| Pubmed ID | 29511454 |
| Year | 2018 |
| Title | Extensive Profiling of Circular RNAs and the Potential Regulatory Role of circRNA-000284 in Cell Proliferation and Invasion of Cervical Cancer via Sponging miR-506 |
External Links
| Links for circ_000284 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |