Basic Information
| LncRNA/CircRNA Name | circDLEU2 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Acute Myeloid Leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, western blot, luciferase reporter assay, other |
| Sample | AML cell lines (MOLM-13, MV-4-11 and HL-60), bone marrow tissue |
| Expression Pattern | up-regulated |
| Function Description | Our data showed that circRNA-DLEU2 was upregulated in AML tissues and cells, which promoted AML cell proliferation and inhibited cell apoptosis. circRNA-DLEU2 promoted AML tumor formation in vivo miR-496 was inhibited by circRNA-DLEU2 and was downregulated in AML tissues. circRNA-DLEU2 inhibited miR-496 expression and promoted PRKACB expression. miR-496 antagonized the effects of PRKACB on MOLM-13 cell proliferation and apoptosis. Collectively, circRNA-DLEU2 accelerated human AML by suppressing miR-496 and promoting PRKACB expression. |
| Pubmed ID | 30037980 |
| Year | 2018 |
| Title | Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia |
External Links
| Links for circDLEU2 | GenBank HGNC NONCODE |
| Links for Acute Myeloid Leukemia | OMIM COSMIC |